Sami Hyypia's side have made a strong start to the season and sit in third position, with 19 points from eight matches. Hoffenheim have racked up 10 points so far, which sees them in mid-table in 10th.
Leverkusen come into this match unbeaten in their last five games, which has included four wins and a draw against leaders Bayern before the international break.
Hyypia's side have already recorded some solid wins this season, beating the likes of Hannover, Wolfsburg and Stuttgart in the Bundesliga, as well as Real Sociedad in the Champions League.
Betway price them as favourites at 21/20 (2.05) to take all three points.
Hoffenheim are struggling to find consistent form in the league this season, recording only one win in their last six matches. That win however, did come against fourth-placed Borussia Monchengladbach.
