However, la Celeste still have a chance of claiming an automatic place if they beat their neighbours and Ecuador and Chile do not draw their game in Santiago.
It is far from an ideal scenario but all Uruguay can do is win their game and hope, and Coral price the hosts at 21/20 (2.05) to claim all three points.
Argentina, meanwhile, who are assured of top spot regardless of the result are offered at a seemingly generous price of 5/2 (3.50).
Yet Argentina coach Alejandro Sabella is poised to field a line-up devoid of many first-team stars, with Lionel Messi out and Angel di Maria - who captained the side on Friday - allowed to return to Real Madrid.
